Polymeric‐Micelle‐Based Nanomedicine for siRNA Delivery
Identifieur interne : 002119 ( Main/Exploration ); précédent : 002118; suivant : 002120Polymeric‐Micelle‐Based Nanomedicine for siRNA Delivery
Auteurs : Xi-Qiu Liu [République populaire de Chine] ; Chun-Yang Sun [République populaire de Chine] ; Xian-Zhu Yang [République populaire de Chine] ; Jun Wang [République populaire de Chine]Source :
- Particle & Particle Systems Characterization [ 0934-0866 ] ; 2013-03.
Abstract
Small interfering RNAs (siRNAs) are a rapidly emerging class of innovative nucleic acid medicines for the treatment of diseases such as cancer. However, significant hurdles hamper their clinical application, including poor cellular uptake, instability under physiological conditions, off‐target effects, and possible immunogenicity. The development of suitable delivery systems that protect and efficiently transport siRNA to targeted cells has been pursued. Nanoparticle‐based vectors have been widely investigated as potential candidates for effective siRNA delivery. Among the different nanoparticles, polymeric micelles, which are self‐assembled nanoparticles composed of amphiphilic materials with a core‐shell structure, have attracted great attention in recent years. Polymeric micelles in the range of several tens to hundreds of nanometers can be prepared, regulated, and modified relatively easily. The outer hydrophilic segments can prolong the in vivo lifetime of siRNA to achieve effective accumulation in tumors and can also be modified with cationic charges that interact electrostatically with siRNA and be introduced with different moieties to target specific cells. The inner cores can improve the stability of micelles and serve as payloads for hydrophobic drugs. Here, the barriers impeding siRNA delivery, the different polymeric micelles of siRNA developed to date, their gene silencing or therapeutic activity, and advanced applications for the co‐delivery of drugs and siRNA by these delivery systems are reviewed.
Small interfering RNAs (siRNAs) are a rapidly emerging class of innovative medicines. However, siRNA delivery is the biggest challenge for their clinical application. The barriers impeding siRNA delivery, the different polymeric micelles of siRNA developed to date, their gene silencing or therapeutic activity, and advanced applications for the co‐delivery of drugs and siRNA by these delivery systems are reviewed.
Url:
DOI: 10.1002/ppsc.201200061
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001A55
- to stream Istex, to step Curation: 001A55
- to stream Istex, to step Checkpoint: 000257
- to stream Main, to step Merge: 002143
- to stream Main, to step Curation: 002119
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymeric‐Micelle‐Based Nanomedicine for siRNA Delivery</title><author><name sortKey="Liu, Xi Iu" sort="Liu, Xi Iu" uniqKey="Liu X" first="Xi-Qiu" last="Liu">Xi-Qiu Liu</name></author><author><name sortKey="Sun, Chun Ang" sort="Sun, Chun Ang" uniqKey="Sun C" first="Chun-Yang" last="Sun">Chun-Yang Sun</name></author><author><name sortKey="Yang, Xian Hu" sort="Yang, Xian Hu" uniqKey="Yang X" first="Xian-Zhu" last="Yang">Xian-Zhu Yang</name></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:548A2294B2189631D51C251EB775C6607B498812</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/ppsc.201200061</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-WTZZXJ4X-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001A55</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A55</idno><idno type="wicri:Area/Istex/Curation">001A55</idno><idno type="wicri:Area/Istex/Checkpoint">000257</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000257</idno><idno type="wicri:doubleKey">0934-0866:2013:Liu X:polymeric:micelle:based</idno><idno type="wicri:Area/Main/Merge">002143</idno><idno type="wicri:Area/Main/Curation">002119</idno><idno type="wicri:Area/Main/Exploration">002119</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Polymeric‐Micelle‐Based Nanomedicine for siRNA Delivery</title><author><name sortKey="Liu, Xi Iu" sort="Liu, Xi Iu" uniqKey="Liu X" first="Xi-Qiu" last="Liu">Xi-Qiu Liu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, University of Science and Technology of China, Anhui 230027, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Sun, Chun Ang" sort="Sun, Chun Ang" uniqKey="Sun C" first="Chun-Yang" last="Sun">Chun-Yang Sun</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, University of Science and Technology of China, Anhui 230027, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Yang, Xian Hu" sort="Yang, Xian Hu" uniqKey="Yang X" first="Xian-Zhu" last="Yang">Xian-Zhu Yang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, University of Science and Technology of China, Anhui 230027, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Life Sciences, University of Science and Technology of China, Anhui 230027, Hefei</wicri:regionArea><placeName><settlement type="city">Hefei</settlement><region type="province">Anhui</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Kunshan RNAi Institute, Jiangshu 215300, Kunshan</wicri:regionArea><wicri:noRegion>Kunshan</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Particle & Particle Systems Characterization</title><title level="j" type="alt">PARTICLE AND PARTICLE SYSTEMS CHARACTERIZATION</title><idno type="ISSN">0934-0866</idno><idno type="eISSN">1521-4117</idno><imprint><biblScope unit="vol">30</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="211">211</biblScope><biblScope unit="page" to="228">228</biblScope><biblScope unit="page-count">18</biblScope><date type="published" when="2013-03">2013-03</date></imprint><idno type="ISSN">0934-0866</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0934-0866</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Small interfering RNAs (siRNAs) are a rapidly emerging class of innovative nucleic acid medicines for the treatment of diseases such as cancer. However, significant hurdles hamper their clinical application, including poor cellular uptake, instability under physiological conditions, off‐target effects, and possible immunogenicity. The development of suitable delivery systems that protect and efficiently transport siRNA to targeted cells has been pursued. Nanoparticle‐based vectors have been widely investigated as potential candidates for effective siRNA delivery. Among the different nanoparticles, polymeric micelles, which are self‐assembled nanoparticles composed of amphiphilic materials with a core‐shell structure, have attracted great attention in recent years. Polymeric micelles in the range of several tens to hundreds of nanometers can be prepared, regulated, and modified relatively easily. The outer hydrophilic segments can prolong the in vivo lifetime of siRNA to achieve effective accumulation in tumors and can also be modified with cationic charges that interact electrostatically with siRNA and be introduced with different moieties to target specific cells. The inner cores can improve the stability of micelles and serve as payloads for hydrophobic drugs. Here, the barriers impeding siRNA delivery, the different polymeric micelles of siRNA developed to date, their gene silencing or therapeutic activity, and advanced applications for the co‐delivery of drugs and siRNA by these delivery systems are reviewed.</div><div type="abstract" xml:lang="en">Small interfering RNAs (siRNAs) are a rapidly emerging class of innovative medicines. However, siRNA delivery is the biggest challenge for their clinical application. The barriers impeding siRNA delivery, the different polymeric micelles of siRNA developed to date, their gene silencing or therapeutic activity, and advanced applications for the co‐delivery of drugs and siRNA by these delivery systems are reviewed.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Anhui</li></region><settlement><li>Hefei</li></settlement></list><tree><country name="République populaire de Chine"><region name="Anhui"><name sortKey="Liu, Xi Iu" sort="Liu, Xi Iu" uniqKey="Liu X" first="Xi-Qiu" last="Liu">Xi-Qiu Liu</name></region><name sortKey="Sun, Chun Ang" sort="Sun, Chun Ang" uniqKey="Sun C" first="Chun-Yang" last="Sun">Chun-Yang Sun</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><name sortKey="Yang, Xian Hu" sort="Yang, Xian Hu" uniqKey="Yang X" first="Xian-Zhu" last="Yang">Xian-Zhu Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002119 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002119 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:548A2294B2189631D51C251EB775C6607B498812
|texte= Polymeric‐Micelle‐Based Nanomedicine for siRNA Delivery
}}
| This area was generated with Dilib version V0.6.33. |  |